In which 2009 epic science fiction film directed by James Cameron are the Na'vi the native inhabitants of Pandora? The answer is Avatar.
The film is set in the mid-22nd century on Pandora, a lush, habitable moon orbiting a planet in the Alpha Centauri system. Humans arrive through the Resources Development Administration to mine unobtanium, a valuable mineral, but their operations threaten the Na'vi, Pandora's intelligent indigenous species.
James Cameron wrote and directed Avatar, which stars Sam Worthington as Jake Sully and Zoe Saldaña as Neytiri. The title refers to genetically engineered Na'vi-human bodies that human operators control remotely. Jake uses one of these bodies while working with scientists and gradually becomes sympathetic to the Na'vi way of life.
A common mix-up is treating Pandora as a planet; in the film, it is a moon. Avatar is also sometimes confused with James Cameron's later Avatar sequels, but the 2009 film is the original story that introduces the Na'vi and their world.