House M.D. premiered on the Fox television network in 2004.
The first episode aired on November 16, 2004. It introduced Gregory House, his diagnostic team, and the fictional Princeton-Plainsboro Teaching Hospital. The premiere established the show’s recurring structure: a puzzling medical case, a series of changing diagnoses, and House’s unconventional reasoning.
The series was developed by David Shore and produced for Fox, where it quickly became a major success. Its arrival helped establish medical mystery as the central engine of a character-driven drama rather than presenting only traditional emergency-room stories.
The premiere year is sometimes confused with the year the show ended, 2012, or with later seasons that introduced new team members. The program ultimately ran for eight seasons and concluded after 177 episodes.