In House M.D., the diagnostician Gregory’s surname is House.
Gregory House is the central character of the medical drama, played by Hugh Laurie. The character leads a diagnostic-medicine team at the fictional Princeton-Plainsboro Teaching Hospital in New Jersey. His surname is also the source of the show’s title, although the title refers primarily to the character rather than the hospital.
House’s unusual methods and personality drive the series. He specializes in difficult cases that other doctors have been unable to solve, often using unusual diagnostic theories and risky tests. His name is sometimes associated with Sherlock Holmes because the character was deliberately modeled partly on the famous detective, but Holmes is not House’s surname. The show’s full title, House M.D., uses “M.D.” to identify the protagonist as a medical doctor and distinguish the series from the character’s name alone.