In House M.D., Hugh Laurie plays the brilliant but misanthropic diagnostician Gregory House.
House is the central character of the medical drama, which follows his work solving unusually difficult diagnostic cases. His methods are often unconventional, and his abrasive personality creates conflict with patients, colleagues, and hospital administrators.
The character is known for chronic leg pain, a dependence on pain medication, and a distinctive cane. These traits are connected to an infarction in the quadriceps muscle of his right leg, an event described before the main timeline of the series.
House is also deliberately modeled on Sherlock Holmes. The connection appears in his deductive approach, his address at 221B Baker Street, and the surname Wilson, which echoes Dr. Watson. Hugh Laurie played House throughout all eight seasons of the series.