In House M.D., Gregory House’s leg infarction affects his right leg.
House suffered an infarction in the quadriceps muscle of his right leg, causing permanent muscle damage and chronic pain. The condition occurred before the main events of the series and became a defining part of his character. He walks with a cane and frequently takes Vicodin to control the resulting pain.
The show gradually reveals the history of the injury through flashbacks and conversations. House initially received delayed treatment after doctors misdiagnosed the problem, and the damaged muscle could not simply be restored. His physical disability is therefore linked to both a medical emergency and failures in earlier diagnosis.
The right-leg detail matters because House’s cane, limp, and pain are recurring visual and narrative clues. Some viewers remember only that he has a damaged leg and may switch the side, but the series consistently identifies the affected limb as the right leg.