In House M.D., Gregory House plays electric guitar.
House is shown playing guitar during the series, and the instrument contributes to his image as a highly intelligent but unconventional physician. His musical interests also connect him with Hugh Laurie, who is an accomplished musician and pianist.
The show uses music to reveal House’s private life and to contrast with his abrasive behavior at work. Although House plays other instruments in the broader story, electric guitar is the canonical answer to the recurring instrument question. The instrument should not be confused with the piano, which is more strongly associated with Laurie’s real-life musical performances.