In House M.D., which fictional address is shared by House and Sherlock Holmes?

In House M.D., House's fictional address is 221B Baker Street, matching Sherlock Holmes's famous address.

House is deliberately modeled in part on Sherlock Holmes, and the address is one of the clearest clues to that connection. Sherlock Holmes traditionally lives at 221B Baker Street in London, while Gregory House lives at 221B Baker Street in the series' fictional Princeton setting. The shared address functions as an homage rather than suggesting that House literally lives in London.

Other parallels include House's deductive approach, his unconventional personality, his drug dependence, and his friendship with Dr. James Wilson, whose role echoes Holmes's companion Dr. Watson. Even House's surname resembles “Holmes” in its short, ordinary form and links the character to the detective tradition.

The address is sometimes mistaken for 221A Baker Street, but the canonical Holmes address—and the one associated with House—is 221B Baker Street.