In House M.D., the episode featuring a bus accident that leaves House with amnesia is “House’s Head.”
“House’s Head” is the first part of a two-episode season-four finale. In the episode, Gregory House wakes after a bus accident with a severe headache and incomplete memory. He believes that a crucial medical event occurred before the crash and tries to reconstruct what happened, despite confusion and neurological symptoms.
The episode uses an unusual structure, moving through House’s damaged recollections as he searches for the missing information. It ends with a major cliffhanger involving Amber Volakis, who is later revealed to have been on the bus with House. The story concludes in “Wilson’s Heart,” the companion episode.
“House’s Head” is often remembered alongside “Wilson’s Heart,” but the titles refer to different halves of the same storyline. The former centers on House’s memory and investigation; the latter deals with the medical consequences for Amber and Wilson. The episode originally aired in May 2008.