In House M.D., which disease does Dr. Thirteen inherit from her mother?

In House M.D., Dr. Thirteen inherits Huntington’s disease from her mother.

Huntington’s disease is a genetic neurodegenerative disorder caused by a mutation in the HTT gene. It is typically inherited in an autosomal-dominant pattern, meaning a person who inherits one altered copy has a high risk of developing the condition.

Thirteen’s diagnosis becomes one of the series’ most important long-term storylines. She initially faces uncertainty about her genetic status and later has to confront the implications of a positive result. Her experiences influence her choices about relationships, treatment, disclosure, and future planning.

The condition is not the same as Parkinson’s or Alzheimer’s disease. Huntington’s commonly involves involuntary movements, cognitive changes, and psychiatric symptoms, although its presentation varies between individuals.