In House M.D., which disease does Dr. House have in his leg?

Dr. House has muscle infarction in his leg in House M.D.

The condition results from an infarction, meaning interrupted blood flow, in the quadriceps muscle of House's right thigh. The damage causes chronic pain and contributes to his distinctive limp and dependence on a cane.

House explains that the problem was initially misdiagnosed and that he eventually underwent a risky procedure to remove dead muscle. The treatment saved the leg but left lasting pain and disability. This history is central to the character because it shapes his use of pain medication and many of his conflicts with colleagues.

The condition is sometimes loosely described by viewers as a leg injury or a clot, but the series identifies the underlying problem as muscle infarction. It is not multiple sclerosis or bone cancer, and House's cane is a consequence of the damage rather than the disease's name.