In House M.D., which character dies in the season 4 finale “Wilson’s Heart”?

Amber Volakis dies in the House M.D. season 4 finale “Wilson’s Heart.”

Amber, played by Anne Dudek, is critically injured after riding on a bus with House. The episode reveals that she has taken amantadine, which becomes toxic after her kidneys fail. The poisoning causes severe medical complications that the doctors cannot reverse.

Amber had previously competed for a place on House’s diagnostic team during season 4. Her nickname, “Cutthroat Bitch,” reflected her aggressive competitiveness, but later episodes developed her relationship with James Wilson and gave the character a more vulnerable side.

“Wilson’s Heart” aired immediately after “House’s Head,” forming a two-part storyline. Amber’s death profoundly affects Wilson and contributes to House’s guilt and emotional deterioration. She is not Allison Cameron, Lisa Cuddy, or Stacy Warner, all of whom are separate characters.