In House M.D., which actress plays immunologist Lisa Cuddy?

Lisa Edelstein plays immunologist and hospital administrator Lisa Cuddy in House M.D.

Cuddy is the dean of medicine and hospital administrator at Princeton-Plainsboro Teaching Hospital. Her responsibilities include managing staff, budgets, policy, and the often difficult relationship between the institution and Gregory House. She is also one of the few people with enough authority to challenge or discipline him.

Edelstein's performance presents Cuddy as an accomplished physician and executive balancing institutional rules with the value of House's diagnostic work. The character's medical background is important because Cuddy can understand the clinical stakes while still demanding accountability from the department.

Lisa Cuddy is distinct from the show's other senior doctors. James Wilson leads oncology, while Cuddy's principal role is administration. Edelstein remained a major cast member through the series' seventh season and did not appear as a regular in the final season.