In House M.D., Gregory House famously misuses Vicodin.
Vicodin is a brand name for a prescription combination of hydrocodone and paracetamol, also called acetaminophen. The show portrays House taking it to manage chronic leg pain caused by an earlier muscle infarction, while also depicting dependence and the professional consequences of his use.
House's medication storyline is a fictional character arc, not a recommendation for treating chronic pain. Hydrocodone is an opioid, and misuse can lead to dependence, overdose, and other serious harms; paracetamol can also damage the liver in excessive amounts.
The drug is sometimes incorrectly identified as OxyContin because both are opioid-related medicines. They are different products: Vicodin combines hydrocodone with paracetamol, whereas OxyContin is an extended-release oxycodone formulation.