In House M.D., what neurological disease does Remy Hadley fear inheriting?

In House M.D., Remy Hadley fears inheriting Huntington’s disease.

Hadley’s mother died from Huntington’s disease, an inherited neurodegenerative disorder. Because the condition is caused by a mutation in the HTT gene and follows an autosomal-dominant inheritance pattern, each child of an affected parent has a 50 percent chance of inheriting the mutation.

This risk becomes one of Hadley’s defining personal conflicts. She delays genetic testing because a positive result would show that she is likely to develop the disease, while a negative result would remove the inherited threat. The storyline examines uncertainty rather than presenting Huntington’s as an ordinary infectious illness.

Hadley’s nickname, “Thirteen,” is separate from the disease storyline: House gives her that name because she was contestant thirteen during the hiring process. The show uses her possible diagnosis to explore testing, reproductive decisions, family history, and the emotional burden of predictive medicine.