In House, M.D., what is the title of the season 4 finale in which Amber dies?

In House, M.D., the season 4 finale in which Amber dies is titled “Wilson’s Heart.”

The episode follows “House’s Head,” creating a two-part story. House is trying to reconstruct events from a night he cannot remember, while the doctors investigate the cause of Amber Volakis’s critical condition. The mystery connects House’s damaged memory, Amber’s illness, and Wilson’s personal relationship with her.

Amber dies after taking amantadine for influenza. Because she has kidney damage from the bus accident, her body cannot properly eliminate the drug and its metabolites. The resulting toxicity causes severe organ damage. The episode’s medical explanation is intertwined with the emotional consequences for Wilson, who had been dating Amber.

“Wilson’s Heart” is often paired with “House’s Head,” but they are separate episode titles. “House’s Head” is the first part and centers on House’s fragmented recollection; “Wilson’s Heart” is the second part and concludes Amber’s storyline. The title emphasizes the episode’s effect on Wilson as much as its medical plot.