James Wilson’s surname is Wilson; he is Gregory House’s best friend and an oncologist at Princeton-Plainsboro in House M.D.
Wilson is played by Robert Sean Leonard. As head of oncology, he treats cancer patients while also serving as House’s most reliable personal connection. Their friendship is central to the series because Wilson often understands House better than House’s other colleagues do.
The pair’s relationship echoes Sherlock Holmes and Dr. Watson, one of the show’s major literary influences. Wilson is not simply a medical assistant: he challenges House’s decisions, supports him during crises, and sometimes suffers the consequences of House’s impulsive behavior.
Wilson’s personal life is repeatedly affected by his willingness to help House. Their friendship remains one of the show’s emotional anchors, even when professional and ethical disagreements put it under pressure.