In House M.D., Vicodin is the pain medication to which Gregory House becomes addicted.
Vicodin is a brand name for a combination of hydrocodone and acetaminophen. In the series, House uses it to manage chronic pain caused by an infarction in the quadriceps muscle of his right leg. He walks with a cane and has a persistent limp, making pain management a constant part of his character and medical storyline.
House’s use of Vicodin begins as treatment for physical pain but develops into dependence and addiction. The show repeatedly examines the effects on his judgment, relationships, employment, and medical practice. At different points, House attempts to stop taking the drug, undergoes detoxification, or hides his use from colleagues. His addiction is portrayed as both a medical problem and a source of dramatic conflict.
The drug is sometimes confused with other prescription opioids, but the series specifically identifies House’s medication as Vicodin. Because Vicodin also contains acetaminophen, excessive use can create serious liver risks in addition to the dangers associated with hydrocodone dependence.