In House M.D., what is the name of House’s longtime best friend and oncologist?

James Wilson is House’s longtime best friend and the hospital’s oncologist in House M.D.

Wilson is portrayed by Robert Sean Leonard and serves as the head of the Department of Oncology at Princeton-Plainsboro Teaching Hospital. His friendship with House provides one of the show’s main emotional relationships: Wilson is generally more empathetic and socially responsible, while House is suspicious, sarcastic, and willing to break rules.

Wilson’s personal life is repeatedly affected by House’s behavior, although Wilson often remains one of the few people willing to defend or understand him. The series also explores Wilson’s marriages, family relationships, and romantic connections, including his relationship with Amber Volakis.

In the final season, Wilson is diagnosed with terminal thymoma. That diagnosis drives the emotional storyline leading to the series finale, in which House chooses to spend Wilson’s remaining time with him rather than remain publicly presumed dead.