In House M.D., what is the name of House's leg condition caused by an infarction?

The story behind the answer

House’s leg condition in House M.D. is muscle infarction.

Before the series begins, Gregory House suffers an infarction in the quadriceps muscle of his right leg. The infarction cuts off blood supply to the muscle, causing tissue damage and leaving House with permanent pain, weakness, and a pronounced limp.

House initially undergoes treatment that includes surgery, but he continues to experience severe chronic pain. He uses a cane and becomes dependent on Vicodin, a central part of the character’s medical and personal story. The show repeatedly connects his physical condition with his irritability, risk-taking, and refusal to accept ordinary limitations.

The condition is not the same as a broken bone or a generic nerve disorder. An infarction is tissue death caused by inadequate blood supply, and in House’s case it affects muscle. The series also reveals that the injury and its treatment are more complicated than House’s public account initially suggests, making the leg condition important both medically and dramatically.

Source: Wikipedia · fact-checked Oct. 2026

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