In House M.D., what is the name of House’s fictional apartment number?

House’s apartment in House M.D. is numbered 221B Baker Street.

The address is a direct reference to 221B Baker Street, the fictional London home of Sherlock Holmes. House is modeled in several ways on Holmes: both are exceptionally observant investigators, both use unconventional reasoning, and both have a close companion whose surname is Wilson rather than Watson.

The parallel is also reflected in House’s name, which can suggest “Holmes” through the detective framework and the show’s emphasis on solving puzzles. These references are influences and homages, not a claim that House is literally Sherlock Holmes in the story.

The apartment number is therefore easy to mix up with famous addresses from other fictional worlds. It is not House’s hospital location, and it refers to the Sherlock Holmes-inspired residence associated with his home life.