In House M.D., what is the name of House’s closest friend, Dr. Wilson?

House’s closest friend in House M.D. is Dr. James Wilson.

Robert Sean Leonard plays James Evan Wilson, an oncologist and the head of Princeton-Plainsboro’s oncology department. Wilson is one of the show’s central supporting characters and provides a moral, emotional, and practical counterweight to House’s abrasive personality.

The friendship is unusual because Wilson repeatedly protects or supports House despite the damage House can cause. At the same time, Wilson is not simply an admirer: he challenges House, criticizes his choices, and sometimes refuses to enable him. Their relationship becomes especially important in the final season.

The name James Wilson is occasionally shortened to Wilson, which can make the character’s first name less familiar. Eric Foreman, Robert Chase, and Lawrence Kutner are members of House’s diagnostic teams, not the friend identified by the question.