In House M.D., Gregory House’s best friend and head of oncology is James Wilson.
Wilson is an oncologist at Princeton-Plainsboro Teaching Hospital and one of the few people who consistently understands House’s motives. Their friendship is central to the series, even though House’s selfishness and Wilson’s willingness to help others repeatedly create conflict between them.
Wilson’s oncology role gives him a separate relationship with patients from House’s diagnostic work. He treats people with cancer, while House investigates obscure conditions affecting patients across the hospital. The two doctors often discuss difficult cases, ethics, relationships, and the consequences of House’s choices.
Robert Sean Leonard played Wilson throughout the series. Wilson is also notable for his several marriages, his compassionate personality, and his complicated loyalty to House. Their friendship remains important even when Wilson objects to House’s conduct or tries to distance himself from it.