In House M.D., what is the name of Dr. House's closest friend and oncologist?

In House M.D., Dr. James Wilson is House's closest friend and an oncologist.

Wilson leads the oncology department at Princeton-Plainsboro Teaching Hospital. His work involves diagnosing and treating cancer, and the emotional demands of that specialty contribute to his compassionate, patient-focused perspective.

His friendship with House is one of the series' central relationships. Wilson often challenges House's decisions, helps him through personal crises, and acts as a bridge between House and other colleagues. At the same time, Wilson's willingness to enable or excuse House can create serious conflict.

The character is played by Robert Sean Leonard. House and Wilson are not members of the same specialty: House directs diagnostic medicine, while Wilson is an oncologist. Their different professional approaches are part of the reason their conversations frequently explore both medical ethics and personal responsibility.