In House M.D., what is the name of Dr. Gregory House's best friend?

Dr. James Wilson is Dr. Gregory House’s best friend in House M.D.

Wilson is an oncologist at Princeton-Plainsboro Teaching Hospital and is portrayed by Robert Sean Leonard. He provides House with emotional support, practical advice, and a moral counterpoint, even though House’s behavior frequently tests their friendship.

Their relationship is one of the show’s most important continuing stories. Wilson often understands House better than other colleagues do, while House repeatedly relies on Wilson despite resisting emotional openness. The pair’s contrasting personalities—House’s cynicism and Wilson’s empathy—create much of the series’ dramatic and comic tension.

James Wilson is the character’s full name; Robert Sean Leonard is the actor’s name. Wilson should also not be confused with Dr. Lisa Cuddy, House’s hospital administrator and another major character. Wilson’s specialty is oncology, the medical field focused on cancer and its treatment.