In House M.D., what is Dr. House's surname?

In House M.D., Dr. Gregory House's surname is House.

“House” is the character's family name and the reason the series is titled House. His full name is Gregory House, but patients, colleagues, and viewers almost always refer to him by his surname. The title also echoes the character's connection to Sherlock Holmes, whose surname resembles “Holmes” and whose investigative style influenced the show.

House is a board-certified diagnostician in the series and leads a specialized team that investigates cases other doctors have been unable to solve. His name appears in hospital records, office signage, and conversations with administrators, although the character's reputation often makes the surname feel like a nickname.

The surname should not be confused with Princeton-Plainsboro, the fictional hospital where House works, or with Wilson, his closest friend. It also does not refer to a real physician. Gregory House is a fictional character created for television, played by Hugh Laurie from the premiere through the finale.