Gregory House often plays the piano in House M.D. His musical ability is one of the recurring details used to show his intelligence, solitude, and intense concentration.
House also plays guitar, and the series occasionally shows him using both instruments. The piano, however, is the clearest answer when the character’s recurring keyboard performances are referenced.
Music is part of House’s routine outside the hospital. He listens to records, plays instruments, and sometimes uses music as a way to distract himself or think through a diagnostic problem.
The instrument is not simply a decorative character detail. House’s musical interests echo the show’s broader portrait of him as technically gifted but socially difficult. His playing should not be confused with Hugh Laurie’s real musical career, although Laurie is also an accomplished musician.