In House M.D., what drug poisoning causes Amber’s death in “Wilson’s Heart”?

In House M.D., amantadine poisoning causes Amber’s death in “Wilson’s Heart.”

Amber Volakis is critically injured when a bus carrying her and Gregory House crashes. At first, the medical team struggles to identify why her condition is worsening. The decisive clue is that Amber had taken amantadine, an antiviral medication, before the crash because she was helping House get home.

The crash damaged her kidneys, preventing her body from clearing the drug. The resulting amantadine toxicity causes severe organ failure, and the doctors determine that she cannot survive. Wilson, Amber’s partner, must then face the loss while House struggles with guilt over the circumstances that brought her onto the bus.

“Wilson’s Heart” is the second part of the season-four finale, following “House’s Head.” Its medical mystery is closely tied to the emotional storyline, which is why the drug is often remembered as the key explanation for Amber’s death rather than the crash alone.