In House M.D., what disease does Amber Volakis have after the bus accident?

Amber Volakis has amantadine poisoning after the bus accident in House M.D.

Amber becomes ill after taking amantadine, an antiviral and Parkinson’s disease medication, for flu symptoms. She is then involved in a bus accident while traveling with Gregory House. Because the medication remains in her system and her kidneys are impaired, the drug becomes dangerously toxic.

The storyline unfolds in the two-part season-four finale, “House’s Head” and “Wilson’s Heart.” The diagnostic mystery initially focuses on House’s incomplete memories of the accident and the identity of the injured passenger. The later episode reveals that Amber is the patient and connects her condition to amantadine toxicity.

The answer is often confused with other poisoning diagnoses in medical dramas. In this case, the key drug is amantadine, not a household gas or a cardiac medication. Amber’s death also becomes a major turning point in Wilson’s relationship with House.