In House M.D., what diagnostic method does House often use to solve cases?

House often solves cases in House M.D. through differential diagnosis.

A differential diagnosis is a systematic list of possible conditions that could explain a patient's signs and symptoms. House and his team develop competing hypotheses, order tests, and eliminate diagnoses as new evidence appears. The process is central to the show's medical structure.

The series dramatizes this method by having House lead rapid discussions with his fellows in the diagnostic department. The team frequently revises its conclusions when a test produces an unexpected result or when a patient's condition changes.

Real clinicians also use differential diagnosis, but the television version is compressed for storytelling. The show often presents rare diseases and dramatic diagnostic reversals, whereas ordinary medical practice commonly involves more frequent conditions and longer evaluation periods.