In House M.D., Gregory House commonly carries Vicodin in an orange pill bottle.
The orange bottle is a recurring visual detail associated with House’s chronic leg pain and dependence on the opioid painkiller. He takes Vicodin after a past vascular event damaged the muscles in his thigh, leaving him with lasting pain and a limp.
House’s medication use becomes a major plot element, affecting his relationships, medical judgment, employment, and attempts at rehabilitation. The bottle’s color is a prop detail, while Vicodin itself is a brand name for a combination of hydrocodone and acetaminophen. The show’s depiction is fictionalized and should not be treated as medical guidance.