The first season of House M.D. contains 22 episodes. Season 1 introduced Gregory House, his diagnostic team, Princeton-Plainsboro, and the show’s recurring format of solving unusual medical cases.
The season began with the pilot and concluded with “Honeymoon,” which first aired in May 2005. Its episodes established the original team of Robert Chase, Allison Cameron, and Eric Foreman, alongside House and his closest friend, oncologist James Wilson.
Season 1 also includes “Three Stories,” the acclaimed episode that uses three patient cases to reveal important parts of House’s medical history. That episode is number 21 in the season, immediately before the finale.
The figure is sometimes confused with the total number of episodes in later seasons, since the series frequently produced seasons in the low twenties. The complete series has 177 episodes, but the first season specifically has 22.